Table 2.
Control values of mean arterial pressure and renal parameters obtained during pretreatment of drugs (l-NAME, tempol, amiloride and furosemide) and cholesterol-vehicle prior to administration of cholesterol
| Group of Rats | n | MAP, mmHg | RVR, mmHg·ml−1·min−1·g−1 | RBF, ml·min−1·g−1 | GFR, ml·min−1·g−1 | V, μl·min−1·g−1 | UNaV, μmol·min−1·g−1 | FENa, % | UNOxV, nmol·min−1·g−1 |
|---|---|---|---|---|---|---|---|---|---|
| Vehicle pretreated | 8 | 113±3 | 15.6±0.7 | 7.2±0.3 | 0.85±0.04 | 10.4±0.8 | 0.97±0.05 | 0.74±0.04 | 0.23±0.02 |
| l-NAME pretreated | 6 | 120±4 | 22.7±0.9* | 5.2±0.3* | 0.85±0.02 | 8.6±1.0* | 0.72±0.05* | 0.60±0.03* | 0.16±0.02* |
| Tempol pretreated | 6 | 115±4 | 15.3±0.8 | 7.5±0.5 | 0.91±0.06 | 9.9±0.7 | 0.95±0.04 | 0.75±0.03 | 0.28±0.04 |
| Amiloride pretreated | 5 | 114±2 | 15.1±1.0 | 7.6±0.5 | 0.84±0.06 | 10.9±1.2 | 2.16±0.24* | 1.83±0.19* | 0.24±0.03 |
| Furosemide pretreated | 6 | 115±3 | 14.7±1.0 | 7.9±0.6 | 0.94±0.04 | 16.5±2.2* | 2.27±0.27* | 1.92±0.22* | 0.26±0.02 |
Values are means ± SE.
*
Significant difference vs. values in vehicle pretreated group (P < 0.05).