Table 4.
Selected patient and tumor characteristics and response to CCRT in comparison to excision repair genes and MMP9 status.
| ERCC1 | ERCC1 | ERCC1 C8092A/ | ERCC2- | ERCC2- | XRCC1- | MMP9 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Primary site | Gender | Age | Response | (IHC) | (mRNA) | CD3EAP Q504K# | 312# | 751# | 399# | (mRNA) |
| (1) | Oral Cavity | W | 69 | PR | N | H | A/A | Asn/Asp | Gln/Lys | Arg/Arg | H |
| (2) | Oral Cavity | M | 66 | PR | P | H | C/C | Asp/Asp | Lys/Lys | Arg/Arg | H |
| (3) | Oral Cavity | M | 59 | PR | P | L | C/C | Asp/Asp | Lys/Lys | Arg/Arg | H |
| (4) | Oral Cavity | M | 82 | CR | P | H | C/C | Asp/Asp | Lys/Lys | Gln/Arg | H |
| (5) | Oral Cavity | M | 61 | NE | P | L | A/C | Asp/Asp⋀ | Gln/Lys | Gln/Arg | L |
| (6) | Oral Cavity | M | 69 | PD | P | L | A/C* | Asn/Asn* | Gln/Gln* | Gln/Gln* | L |
| (7) | Oral Cavity | W | 41 | PD | P | L | A/C* | Asn/Asp* | Gln/Lys* | Gln/Arg* | L |
| (8) | Oral Cavity | W | 60 | CR | P | H | C/C | Asp/Asp | Lys/Lys | Gln/Arg | H |
| (9) | Oral Cavity | M | 44 | CR | P | H | C/C | Asn/Asn | Gln/Gln | Arg/Arg | H |
| (10) | Oral Cavity | M | 60 | ED | P | L | C/C | undet. | undet. | undet. | L |
| (11) | Oral Cavity | W | 59 | PD | P | L | A/C | Asn/Asp | Gln/Lys | Arg/Arg | H |
| (12) | Oral Cavity | W | 55 | CR | Undet. | Undet. | A/C | Asp/Asp | Lys/Lys | Gln/Arg | Undet. |
| (13) | Oropharynx | M | 57 | CR | P | H | C/C | undet. | undet. | undet. | H |
| (14) | Oropharynx | W | 36 | CR | P | L | C/C | Asn/Asp | Gln/Gln | Gln/Arg | H |
| (15) | Oropharynx | M | 59 | CR | P | L | A/C | Asn/Asp | Gln/Lys | Gln/Arg | L |
| (16) | Oropharynx | W | 55 | CR | N | H | A/C | Asn/Asp | Gln/Lys | Arg/Arg | H |
| (17) | Oropharynx | M | 69 | PR | P | Undet. | A/C | Asn/Asn | Gln/Lys | Gln/Arg | Undet. |
| (18) | Oropharynx | M | 46 | CR | N | L | C/C | Asn/Asp | Gln/Lys | Arg/Arg | L |
| (19) | Oropharynx | M | 73 | PD | P | L | C/C | Asp/Asp⋀ | Gln/Lys | Gln/Gln | L |
| (20) | Oropharynx | M | 67 | SD | P | H | A/A | Asn/Asn | Gln/Gln | Gln/Arg | L |
| (21) | Hypopharynx | M | 46 | CR | P | H | A/C | Asn/Asp | Gln/Lys | Gln/Arg | H |
| (22) | Hypopharynx | W | 64 | PR | N | H | C/C | Asp/Asp | Lys/Lys | Arg/Arg | L |
| (23) | Hypopharynx | M | 56 | ED | P | L | A/C | Asn/Asp⋀ | Lys/Lys | Gln/Arg | L |
| (24) | Hypopharynx | W | 56 | PR | P | L | C/C* | Asn/Asp* | Gln/Lys* | Gln/Arg* | H |
| (25) | Larynx | M | 55 | CR | N | H | A/C | Asn/Asp | Gln/Lys | Gln/Arg | H |
| (26) | Larynx | M | 68 | PR | N | L | A/A | Asp/Asp | Lys/Lys | Arg/Arg | L |
| (27) | Larynx | M | 60 | ED | — | Undet. | — | — | — | — | Undet. |
| (28) | Larynx | M | 42 | PR | P | N | C/C | Asn/Asn | Gln/Lys | Gln/Gln | H |
| (29) | Larynx | M | 76 | CR | P | H | A/C | Asn/Asp | Gln/Gln | Gln/Arg | L |
| (30) | Larynx | M | 74 | ED | P | N | C/C | Asn/Asp | Gln/Lys | Arg/Arg | L |
| (31) | Larynx | W | 46 | SD | P | N | A/C | Asn/Asp | Gln/Lys | Gln/Arg | L |
| (32) | Larynx | M | 74 | ED | N | H | A/A⋀ | Asn/Asp | Lys/Lys | Gln/Arg | L |
| (33) | Larynx | M | 67 | PD | N | H | C/C | Asp/Asp | Lys/Lys | Arg/Arg | L |
| (34) | Larynx | M | 54 | CR | P | N | C/C | Asp/Asp | Lys/Lys | Arg/Arg | L |
| (35) | Larynx | M | 54 | PR | P | Undet. | A/C | Asn/Asp | Gln/Lys | Gln/Arg | Undet. |
| (36) | Paranasal Sinuses | M | 65 | SD | P | H | C/C | Asp/Asp | Gln/Lys | Gln/Arg | H |
| (37) | Major Salivary Glands | M | 74 | PR | P | H | C/C | Asp/Asp | Gln/Lys | Gln/Arg | H |
n = sample order number; M = man; W = woman; H = high; L = low; P = positive; N = negative; # = genotypes from tumor tissue or from matched peripheral blood and tumor tissue samples, unless otherwise specified; ⋀ = mismatched tumor/peripheral blood genotypes (tumor data are shown); * = peripheral blood data only; Undet. = undetermined by real time PCR.