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. 2009 Dec 24;2009:780874. doi: 10.1155/2009/780874

Figure 5.

Figure 5

Both wild type and dominant negative AP-2 inhibit endogenous c-myc expression. HaCaT cells were infected with Ad-Bgl II (Control), wild type AP-2α, dominant negative AP-2, or c-MYC adenovirus at 100 MOI. Twenty-four hours later, nuclear protein and total RNA were extracted. (a) c-MYC mRNA level decreased to about 50% compared to control group after AP-2 infection (*P < .05 versus BglII control, n = 3). (b) c-MYC protein level decreased after AP-2 infection, The fourth lane is a positive control sample from Ad-c-MYC infected HaCaT cells (representative blot of three independent experiments).