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. Author manuscript; available in PMC: 2010 Nov 12.
Published in final edited form as: J Med Chem. 2009 Nov 12;52(21):6912–6918. doi: 10.1021/jm901220m

Figure 2.

Figure 2

Results of the comparative library screens with all potential inhibitors at a nominal concentration of 5 µM. A) Screening for LYP inhibition using the substrate DiFMUP (grey) and peptide 1 (black). B) Selected hits from a DiFMUP-based screen for LYP (striped) and PTP-PEST (shaded) inhibitors. C) Selected hits from a peptide 1-based screen for LYP (striped) and PTP-PEST (shaded) inhibitors. D) Selected hits from a PTP1B inhibitor screen using the substrates DiFMUP (grey) and peptide 2 (black). E) Selected hits from a TCPTP inhibitor screen using the substrates DiFMUP (grey) and peptide 2 (black).