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IC50 data for hits from the PTP1B/TCPTP screen in µM.
| Cmpd # | Phosphine | PTP1B (DiFMUP) |
PTP1B (peptide 2) |
TCPTP (DiFMUP) |
TCPTP (peptide 2) |
|---|---|---|---|---|---|
| 18 | P(p-SO3H-Ph)2(Ph) | 16±1 | 15±1 | 16±1 | 7.5±0.3 |
| 19 | P(2-furyl)3 | 0.33±0.02 | 0.20±0.02 | 2.4±0.2 | 2.2±0.3 |
| 40 | P(F5Ph)3 | 7.5±0.2 | 5.4±0.3 | 6.7±0.2 | 57±1 |
