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. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: Neuropharmacology. 2009 Aug 19;57(7-8):694–701. doi: 10.1016/j.neuropharm.2009.08.002

Table 5.

Transport Kinetics of NET Variants

hNET Variant	[³H]NE Transport		[³H]DA Transport

	K_M(μM)	V_MAX(%NET)	K_M (μM)	V_MAX(%NET)

hNET	1.5 ± 0.4	100.0 ± 0.0	0.3 ± 0.1	100.0 ± 0.0
V245I	1.1 ± 0.4	76.2 ± 15.4	0.2 ± 0.1	78.2 ± 15.6^*
T283M	1.4 ± 0.4	84.3 ± 5.2	0.2 ± 0.1	72.1 ± 10.3^*
T283R	0.7 ± 0.4	33.6 ± 3.6^*	0.09 ± 0.07	50.6 ± 17.1^*

^*

, significantly different from NET, p < 0.05.