Table 4. Description of top-ranked genes.
| Gene (Alias) | Chromosome | Gene Description* | Gene ontology** | Additional Comments | Selected References |
| DNA repair | |||||
| DMC1 | 17q25.1 ?22q13.1 | Dosage suppressor of mck1 homolog, meiosis-specific homologous recombination | Female gamete generation; meiosis; reciprocal meiotic recombination; spermatogenesis; ATP binding; DNA binding | Rad51 homolog, meiosis | (6) |
| DUT | 15q15-q21.1 | Deoxyuridine triphosphatase | DNA replication; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; dUTP disphosphatase activity | Modulation of nucleotide pools | (6) |
| FLJ35220 (ENDOV) | 17q25.3 | Hypothetical protein FLJ35220 | Editing/processing nucleases; incision 3′ of hypoxanthine and uracil | (6) | |
| GTF2H4 | 6p21.3 | General transcription factor IIH, polypeptide 4 | DNA repair; nucleotide-excision repair, DNA damage removal; RNA elongation from RNA polymerase II promoter | Nucleotide excision repair; core TFIIH subunit p52 | (6) |
| POLN (POL4P) | 4p16.2 | Polymerase (DNA directed) nu | DNA-dependent DNA replication; DNA-directed DNA polymerase activity | DNA polymerase; DNA crosslink repair | (6) |
| HPV binding/immune-related genes | |||||
| IFNG | 12q14 | Interferon, gamma | Cell cycle arrest; cell motion; signal tranduction | Cytokine with role in innate/adaptive immunity against viral/bacterial infections; role in tumor control | OMIM |
| OAS1 | 12q24.2 | 2′-5′-oligoadenylate synthetase 1 | Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Role in resistance to viral infection via degradation of viral and cellular RNAs and impairment of viral replication. Also implicated in control of cell growth, differentiation, and apoptosis. | OMIM |
| OAS2 | 12q24.2 | 2′-5′-oligoadenylate synthetase 2 | Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Resistance to viral infection (see OAS1) | OMIM |
| OAS3 | 12q24.2 | 2′-5′-oligoadenylate synthetase 3 | Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Resistance to viral infection (see OAS1) | OMIM |
| SULF1 | 8q13.3 | Sulfatase 1 | Heparin sulfate proteoglycan metabolic process; arylsulfatase activity | Coreceptor for heparin-binding growth factors and cytokines; involved in cell signaling | OMIM |
| TMC8 (EVER2) | 17q25.3 | Transmembrane channel-like 8 | Epidermodysplasia verruciformis susceptibility gene | (20) | |
| TMC6 (EVER1) | 17q25.3 | Transmembrane channel-like 6 | Epidermodysplasia verruciformis susceptibility gene | (20) | |
*
As defined in NCBI Entrez Gene (http://www.ncbi.nlm.nih.gov/sites/entrez); **Gene Ontology annotation (http://www.geneontology.org/); OMIM: http://www.ncbi.nlm.nih.gov/sites/entrez; GeneCards: http://www.genecards.org; (1) Supplement to Wood RD, Mitchell M, Lindahl T Mutation Research 2005 (http://www.cgal.icnet.uk/DNA_Repair_Genes.html); (2) Orth G. Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis. Curr Top Microbiol Immunol. 2008;321:59-83.