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. 2010 Jan 13;5(1):e8626. doi: 10.1371/journal.pone.0008626

Figure 3. Mutations in Ctr1, Atox1 and dFKBP59 alter levels of Cu in Drosophila heads and mouse cells.

Figure 3

(A–B) Copper measurements in Drosophila heads. (A) Control flies (oreR), flies expressing Aβ42 (Abeta) or flies over-expressing Ctr1A (UAS-Ctr1). (B) Wild type flies (oreR) and flies carrying loss-of-function mutations in the Atox1 and FKBP59 genes. Stars denote statistical significance. (C–D) Copper measurements in MEF cells. (C) intracellular copper in cells treated with BCS. (D) Intracellular copper in FKBP52 knock-out MEF cells.