Table 1. Effects of dFKBP59 and copper transporter mutations on the Aβ42-induced rough eye phenotype.
| Mutation type | Rough eye phenotype (%±SEM) | Effect | ||||
| mild | moderate | severe | ||||
| (29°C)*** | Aβ only | -- | 27±0 | 29.5±1.5 | 43±1 | -- |
| UAS-Ctr1A | gof * | 2.5±2.5 p<0.01 | 10.2±2.3 p<0.02 | 87.25±4.8 p<0.01 | enhancer | |
| dFKbp59EY03538 | gof | 54.5±9.6 p<0.1 | 26±5 p<0.5 | 19±5 p<0.04 | suppressor | |
| (25°C) | Aβonly | -- | 50±7 | 47.5±5.5 | 2.2±1.8 | -- |
| Atox1e01272 | lof ** | 15.67±8.95 p<0.07 | 28±5.1 p<0.08 | 56.00±9.5 p<0.02 | enhancer | |
| Atox1EY15780 | lof | 12.33±6.9 p<0.03 | 27.67±1.33 p<0.02 | 60.33±7.3 p<0.009 | enhancer | |
| Atox1f00729 | lof | 14.5±5.5 p<0.05 | 57±2 p<0.2 | 28.5±3.53 p<0.02 | enhancer | |
| dFKbp59c01413 | lof | 11±6 p<0.02 | 22.7±8.2 p<0.1 | 66.3±8.77 p<0.01 | enhancer | |
| dFKbp59k00424 | lof | 42.5±9.6 p<0.6 | 43.5±9.6 p<0.7 | 13.5±0.5 p<0.02 | enhancer | |
| dFKbp59k09010 | lof | 15.5±15.6 p<0.1 | 48±6 p<0.9 | 36.5±9.6 p<0.07 | enhancer | |
*gain-of-function mutation.
**loss-of-function mutation.
***For maximum expression, flies with the UAS/Gal4 system were raised at 29°C. All loss-of-function mutants were raised at 25°C.