Figure 7.

MMP-8^−/− recipients show less luminal obliteration. Grafts were explanted 14 days post-transplantation (n=6). Comparison of WT and MMP-8^−/− recipients stained with H&E at 40× original magnification shows a higher percentage of luminal obliteration in WT recipients (A) compared with MMP-8^−/− recipients (B). Histopathologic grading of H&E-stained samples demonstrates median obliteration was significantly lower in MMP-8^−/− animals (1.25 vs. 3.5; P=0.028; C). Quantitative measurement of the area of luminal obstruction by image analysis demonstrated significantly less obstruction in MMP-8^−/− recipients (52.8%±5.8 vs. 32.4%±5.2; *, P=0.026; D).