Table 7.

Multivariate Cox proportional hazards analysis of association of the rs2808630 genotypes and composite outcomes and other clinical predictors

Variable	Hazard Ratio (95% CI)	P Valuea
Genotype
rs2808630_AA	Ref
rs2808630_AG	0.87 (0.59, 1.29)	0.49
rs2808630_GG	3.65 (1.62, 8.23)	0.002b
BP assignmentc	0.78 (0.55, 1.12)	0.19
Drug assignment
Calcium channel blockers	Ref
β blockers	0.72 (0.44, 1.17)	0.19
ACE inhibitors	0.56 (0.34, 0.91)	0.02
Log CRP (mg/dl)	0.96 (0.81, 1.14)	0.65
Age	1.01 (0.99, 1.02)	0.53
Genderd	1.04 (0.71, 1.52)	0.83
Body mass index (kg/m2)	0.98 (0.95, 1.02)	0.32
Mean baseline GFR (ml/min)	0.96 (0.94, 0.97)	<0.0001
Urine protein (g/d)	1.88 (1.64, 2.17)	<0.0001
Number of comorbidities	1.04 (0.85, 1.26)	0.72
Smoking (current versus never or former)	1.63 (1.11, 2.40)	0.01

Adjustement done for baseline covariates.

BP assignment: usual: MAP 102–107 mmgh; low: MAP <92 mmgh.

Mean baseline GFR: the mean of two GFR measurements by isothalamate.

^aUnadjusted for multiple comparisons.

^bStatistical significance at an α = 0.0045 after Bonferroni correction for 11 genotypes.

^cReference group low BP.

^dReference group male.