Table 2.

Baseline characteristics of Framingham Offspring Study participants according to serum uric acid concentrations (n=4912)

		Quartile 1	Quartile 2	Quartile 3	Quartile 4	p value for trend
	Metric	1.2–4.34 mg/dl	4.35–5.2 mg/dl	5.3–6.2 mg/dl	6.3–13.7 mg/dl
Number of participants		1164	1194	1227	1329
Age in years	(mean ± SD)	34± 10	36± 10	36±11	38± 11	<0.001
Proportion of men	%	5	30	65	88	<0.001
Body mass index in kg/m2	(mean ± SD)	23±3	25±4	26±4	28±4	<0.001
Alcohol use	%	81	84	85	90	<0.001
Proportion of current smokers	%	60	65	62	68	<0.001
Diuretic users	%	2	3	4	6	<0.001
Systolic blood pressure in mm Hg	(mean ± SD)	114±13	119±15	123±15	129±17	<0.001
Diastolic blood pressure in mm Hg	(mean ± SD)	73±9	77±10	79±10	84±11	<0.001
Fasting glucose (mg/dl)	(mean ± SD)	93±17	99±23	104±33	108±32	<0.001
Total Cholesterol (mg/dl)	(mean ± SD)	187±37	191±38	199±41	205±40	<0.001
LDL cholesterol (mg//dl)	(mean ± SD)	115±33	121±35	130±36	131±35	<0.001
HDL cholesterol (mg/dl)	(mean ± SD)	57±14	53±15	48±13	45±13	<0.001
Triglycerides (mg/dl)	(mean ± SD)	101±69	112±73	131±107	163±162	<0.001
Serum uric acid (mg/dl)	(mean ± SD)	3.7±0.5	4.8±0.3	5.7±0.3	7.2±0.8
Valvular heart disease	%	8.3	7.7	6.0	7.0	0.16
History of gout at baseline	%	0.1	0.6	0.3	6.9	<0.001
History of diabetes at baseline	%	0.9	1.8	2.7	2.3	0.008

Valvular heart disease was defined for this study as presence of cardiac murmur at baseline. Gout was determined based on physician diagnosis. Diabetes was defined using the American Diabetes Association Criteria and/or use of anti-diabetes medications.