Table 4.

Multivariable adjusted risk of heart failure among various sub-groups of the Framingham Offspring Cohort

	Number of participants in the model	Hazard ratio for each mg/dl increase in serum uric acid	95% confidence interval
No renal dysfunction anytime during the observation	3587	1.3	1.10–1.50
Non-uses of any non-diuretic blood pressure medications	3677	1.20	1.01–1.44
Non-users of diuretics	3639	1.20	1.00–1.41*
Non diabetics	3517	1.28	1.01–1.52
No metabolic syndrome at study end-date	3765	1.26	1.07–1.47

^*p=0.048. Unless specified otherwise, multivariable models were adjusted for : sex, time varying measures of age , smoking systolic blood pressure serum total cholesterol: high density lipoprotein ratio, alcohol use renal dysfunction, coronary artery disease, valvular heart disease, diuretic use and non-diuretic blood pressure medications