Table 1.
Extracellular matrix and integrin expression profile of hESC-derived cardiomyocytes
In vitro | 2 days | 4 weeks | 12 weeks | 4 weeks + MI | 12 weeks + MI | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
hESC-CM | Likely from hESC-CM? | Scar > rest heart? | hESC-CM | Likely from hESC-CM? | Scar > rest heart? | hESC-CM | Likely from hESC-CM? | Scar > rest heart? | hESC-CM | Likely from hESC-CM? | Scar > rest heart? | hESC-CM | Likely from hESC-CM? | Scar > rest heart? | hESC-CM | Likely from hESC-CM? | |
COLL I | X | O | O | X | O | O | X (extra) | O | O | X (extra) | O | X | X (extra) | O | X | X (extra) | O |
HU-COLL IV | X | X | O | X | X | O | X (extra) | X | O | X (extra) | X | O | X (extra) | X | O | X (extra) | X |
HU-COLL XVIII | X | X | O | X | X | O | X (extra) | X | O | X (extra) | X | O | X (extra) | X | X (extra) | X | |
LM | X | X | O | X | ? | O | X | ? | O | X | ? | X | X | ? | X | X | ? |
LM-211 | O | O | O | O | O | O | X | ? | O | X | ? | O | X | ? | O | X | ? |
FN | X | X | X | X | X | X | X (<2 days) | X | O | X (<4 weeks) | X | X (hu > ms) | X | X | X (hu > ms) | X | X |
α1 | O | O | O | O | O | ||||||||||||
α2 | O | O | O | O | O | ||||||||||||
α3 | Some X | Some X | X | X | X | X | |||||||||||
α4 | O | O | O | O | O | ||||||||||||
α5 | X | Most X | Some X | 50% X | Some X | ||||||||||||
α6 | Some X | Some X | O | O | O | ||||||||||||
α7 | X (PCR) | ||||||||||||||||
α10 | O | O | O | O | O | ||||||||||||
α11 | X | X | X | X | X | ||||||||||||
αV | X | most X | 50% X | Some X | 50% X | ||||||||||||
β1 | X | X | X | X | X |
X Yes, O no, (extra) also at distance from the graft, hu human, ms mouse, MI myocardial infarction, coll collagen, LM laminin