Table 1.

A comparison of the main phenotypic characteristics of the mesenchymal and amoeboid modes of invasiveness

Mesenchymal	Amoeboid
Morphology
Elongated	Rounded
Attachment to the ECM
Via integrin clusters creating focal contacts and adhesions	Weak, short-term, integrins diffused in the membrane
Migration in the ECM
ECM degradation, remodeling	Proteolysis-independent pushing through the ECM
Organization of actin cytoskeleton
Actin meshwork (leading edge), stress fibers (traversing the cell)	Contractile actin cortex
Velocity of the locomotion
Low	High
Cell membrane extensions
Filopodia and lamellipodia	Intensive blebbing