Table 4.
Gender differences
| Male (n=48) | Female (n=34) | P-value | |
|---|---|---|---|
| Mutation | 30 (63%) | 13 (38%) | 0.03 |
| Age diagnosis, yrs | 38±16 | 35±10 | 0.35 |
| Age first ARVD related symptoms, yrs | 34±15 | 32±12 | 0.55 |
| Family history, n (%) | 15 (31%) | 16 (47%) | 0.15 |
| Family history proven on autopsy | 9 (19%) | 9 (27%) | 0.40 |
| Repolarization abnormalities, n (%) | 41 (87%) | 32 (94%) | 0.21 |
| Depolarization abnormalities, n (%) | 41 (89%) | 23 (70%) | 0.03 |
| Major depolarization abnormalities | 28 (61%) | 9 (28%) | 0.004 |
| LBBB-VT on ECG, Holter or stress-ECG | 31 (67%) | 16 (47%) | 0.07 |
| Age of first recorded VT | 37±15 | 37±11 | 0.93 |
| Structural alterations, n (%) | 46 (96%) | 32 (94%) | 1.00 |
| Minor dysfunction and structural alterations, n (%) | 20 (42%) | 22 (65%) | 0.04 |
| Major dysfunction and structural alterations, n (%) | 26 (54%) | 10 (29%) | 0.026 |
| Fibrofatty replacement on endomyocardial biopsy, n (%) | 9 (53%) | 4 (25%) | 0.10 |
Repolarization abnormalities are considered present if there is T-wave inversion in ECG leads V1, V2, and V3 for those aged > 14 years in the absence of right bundle branch block. Depolarization abnormalities are considered major if there are epsilon waves or localized prolongation (>110ms) of the QRS complex in right precordial leads (V1–V3), and minor if there are late potentials on signal-averaged ECG. P-values that are below 0.05 are indicated with bold-faced text.