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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Circ Cardiovasc Genet. 2009 May 15;2(4):371–378. doi: 10.1161/CIRCGENETICS.108.832345

Figure 5. Partial correction of pacing-induced gene expression changes by CRT.

Figure 5

A comparison of up- and down-regulated transcripts in KEGG pathways that were differentially expressed between non-failing and failing myocardium (upper panel) and between anterior and lateral LV myocardium (lower panel). Up- and down-regulated transcripts are represented by white and black columns, respectively. CRT partially restores dyssynchrony-induced gene expression changes in failing ventricular myocardium (up regulation of transcripts in oxidative phosphorylation pathways and down regulation of cell signaling pathways in the anterior wall).