Table 2. Summary of association results for rs3742207 (A) and rs1495448 (B).

This table summarizes the association results with PWV for the top SNPs rs3742207 (COL4A1) and rs1495448 (MAGI1). Alleles refer to the forward strand, and are ordered such that the first allele (+) is associated with increased PWV values. Effect sizes and standard errors (in cm/s) are derived from models that analyzed non-normalized PWV, whereas p-values are calculated from models that analyzed the normalized trait as described in the text.

A) COL4A1
Study	N	Allele (+/−)	Freq	Effect (SE)	P-value
SardiNIA	4,221	C/A	0.44	21.0 (4.7)	5.94×10−5
SardiNIA stage 2	1,828	C/A	0.42	15.2 (5.1)	0.0035
Combined SardiNIA					7.08×10−7
Old Order Amish	813	C/A	0.55	16.4 (8.2)	0.0218
Combined SardiNIA and Old Order Amish					5.16×10−8
B) MAGI1
Study	N	Allele (+/−)	Freq	Effect (SE)	P-value
SardiNIA	4,221	T/G	0.42	8.5 (4.5)	2.76×10−4
SardiNIA stage 2	1,828	T/G	0.46	11.0 (5.0)	0.013
Combined SardiNIA					1.07×10−5
Old Order Amish	813	T/G	0.50	2.3 (8.7)	0.49
Combined SardiNIA and Old Order Amish					1.23×10−5