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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Circ Cardiovasc Genet. 2009 May 14;2(4):329–337. doi: 10.1161/CIRCGENETICS.108.834986

Table 2.

Pairwise linkage disequilibrium (LD) and association results of rs495366, rs12289128 and rs11226373

Pairwise LD
(|D’| / r2)		 Geometric mean of MMP-1 levels by
genotypes		 Conditional
P while

added into
the model
sequentially*
RS ID Position MAF
(%)		 With
rs495366		 With
rs12289128		 Geno-
type		 N
(%)		 MMP-1
level
(ng/ml)		 Marginal
P*
rs495366 102,200,318 36.1 --- --- CC 311 (40.6) 3.96 8.39 × 10−23 8.39 × 10−23
CT 358 (46.7) 2.81
TT 98 (12.8) 1.51
rs12289128 102,185,176 14.5 1.0/0.1 --- GG 573 (73.7) 3.08 0.026 6.65 × 10−10
GC 185 (23.8) 2.76
CC 20 (2.6) 2.22
rs11226373 103,839,449 15.2 0.9/0.08 0.03/0.001 TT 555 (71.6) 2.58 1.50 × 10−12 7.85 × 10−07
TC 205 (26.5) 4.18
CC 15 (1.9) 5.21

Abbreviations: MAF, minor allele frequency; N, number of individuals.

*

Genomic control-corrected P value (under additive model), adjusted for baseline covariates (age, age2, sex, age-by-sex and age2-by-sex)