The five unique E2 helices of the free DNA crystal structures. From left to right: E2-R3 (cyan), the three E2-P1 molecules (magenta, orange, and red), and E2-P4 (green). Despite of differences in crystal packing and base sequence, all five duplexes exhibit similar global structures with rms deviations ranging from 0.7 to 1.0 Å using all common atoms. The figure was drawn with setor (14).