Fig. 4. Adenosine antagonists are being investigated as diuretics that improve renal function. In 1 study, the adenosine antagonist BG9719 in combination with furosemide increased urine output while preserving the glomerular filtration rate (GFR).52
Reproduced with permission from: Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, Goldman S, et al. BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy [published erratum appears in Circulation 2002;106(13):1743]. Circulation 2002;105(11):1348–53.52