Table 3.
Entry | Acceptor 2 | MW (W) | Monoglycosylated product 3 | Yield of 3 [1st, 2nd] (%) | Yield of diglycosylated product 4 (%) |
---|---|---|---|---|---|
19 | 0 | 6 [7,4] | n. d. | ||
20 | 2j | 200 | 3j | 5 [4,6] | n. d. |
21 | 0 | 14 [8,19] | n. d. | ||
22 | 2k | 200 | 3k | 19 [10,28] | n. d. |
25 | 0 | 20 [19,21] | n. d. | ||
26 | 2l | 200 | 3l | 17 [16,18] | n. d. |
27 | 0 | 12 [12,12] | 4ma,b 12 [11,12] | ||
28 | 2m | 200 | 3m | 30 [33,26] | 4ma,b |
29 | 0 | 17 [14,20] | 18 [16,20] 4na,b | ||
30 | 2n | 200 | 3n | 21 [23,19] | 17 [15,18] 4na,b 14 [10,17] |
Structure of diglycosylated product 4m and 4n.
The yields of 4m and 4n were calculated as one half molar equivalent of the glycosyl donor 1 was 100%.