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. 2010 Jan;16(1):106–117. doi: 10.1261/rna.1894510

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FIGURE 2. — Comparison of L sshRNA activity with various loop structures and base pairs adjacent to the loop. (A) Loop length comparison, using L sshRNAs against the same target region as sh68 and si19-3, but with various lengths and sequences of loops. sshRNAs were chemically synthesized and their abilities to inhibit HCV IRES-dependent luciferase expression were compared in 293FT cells. (B) Loop-adjacent base-pair comparison. sshRNAs against the same target region as si72, but with loops of 5 nt (SG72 and SG72L) and 2 nt (SG118 and SG103) and left-loop (SG72L and SG118) and right-loop (SG72 and SG103) orientations were compared for their inhibitor activity in 293FT cells. Loop sequences are underlined.