Table 1.
The 52 differentially regulated proteins selected at 14% false discovery rate. The 20 proteins shown in bold belong to the high-confidence list of differentially regulated proteins selected at 5% false discovery rate.
| Locus | Protein description | PCS_IDs | AR | AS | AIS,R | AIS,S | AS/AR |
|---|---|---|---|---|---|---|---|
| (Upregulated proteins) | |||||||
| MSMEG_0614 | Methyltransferase | 2 | 3.58E+05 | 1.29E+06 | 1.79E+05 | 3.20E+05 | 3.61a |
| MSMEG_0969 | Glutamate-1-semialdehyde-2,1-aminomutase (hemL) | 8 | 3.22E+06 | 9.92E+06 | 1.72E+06 | 4.57E+06 | 3.08a |
| MSMEG_1037 | Alcohol dehydrogenase, zinc-containing | 61 | 1.16E+07 | 9.09E+07 | 5.86E+06 | 8.82E+06 | 7.82a |
| MSMEG_1475 | Conserved hypothetical protein | 4 | 6.54E+05 | 2.99E+06 | 6.56E+05 | 6.59E+05 | 4.57a |
| MSMEG_1903 | Caib-baif family | 6 | 2.26E+05 | 8.85E+05 | 9.29E+04 | 6.94E+04 | 3.91a |
| MSMEG_2669 | Hydrolase | 46 | 5.03E+06 | 2.10E+07 | 4.72E+06 | 5.22E+06 | 4.17a |
| MSMEG_2956 | NAD-dependent epimerase-dehydratase family protein | 47 | 1.59E+06 | 1.49E+07 | 6.24E+06 | 7.72E+06 | 9.37ab |
| MSMEG_3932 | 14 kDa antigen | 2 | 2.09E+05 | 2.56E+06 | 5.07E+04 | 4.75E+04 | 12.2 |
| MSMEG_3945 | Universal stress protein family | 14 | 1.08E+06 | 5.22E+06 | 4.01E+05 | 3.21E+05 | 4.83a |
| MSMEG_3950 | Universal stress protein family | 20 | 7.81E+06 | 2.41E+07 | 1.30E+06 | 1.43E+06 | 3.09a |
| MSMEG_4381 | Amidase | 2 | 8.13E+04 | 2.50E+05 | 3.19E+05 | 5.63E+05 | 3.08a |
| MSMEG_4971 | Oxidoreductase | 2 | 1.64E+05 | 5.19E+05 | 1.36E+06 | 9.37E+05 | 3.16a |
| MSMEG_5136 | Helix-turn-helix motif | 8 | 8.36E+05 | 4.53E+06 | 4.69E+04 | 6.80E+04 | 5.42a |
| MSMEG_5164 | Zinc-binding alcohol dehydrogenase family protein | 6 | 3.17E+05 | 1.35E+06 | 3.48E+06 | 8.77E+06 | 4.27a |
| MSMEG_5243 | Helix-turn-helix motif | 4 | 1.14E+06 | 4.35E+06 | 2.33E+05 | 2.07E+05 | 3.82 |
| MSMEG_5245 | Universal stress protein family | 8 | 1.08E+06 | 7.58E+06 | 3.06E+05 | 4.46E+05 | 7.02a |
| MSMEG_5246 | Conserved hypothetical protein | 22 | 1.98E+06 | 1.49E+07 | 2.94E+06 | 2.11E+06 | 7.53a |
| MSMEG_5285 | Phospholipase, patatin family | 14 | 5.80E+05 | 2.26E+06 | 1.42E+05 | 2.21E+05 | 3.90a |
| MSMEG_5419 | Putative lipoprotein | 66 | 4.80E+06 | 1.56E+07 | 3.26E+06 | 3.81E+06 | 3.24 |
| MSMEG_5739 | Putative long-chain fatty-acid–CoA ligase | 16 | 4.23E+05 | 2.36E+06 | 3.81E+05 | 5.32E+05 | 5.57ab |
| MSMEG_6454 | Conserved hypothetical protein | 56 | 8.18E+06 | 4.89E+07 | 3.58E+06 | 3.41E+06 | 5.98a |
| (Down-regulated proteins) | |||||||
| MSMEG_0131 | AMP-binding enzyme, putative | 2 | 9.20E+04 | 2.08E+04 | 9.30E+04 | 7.72E+04 | 0.23a |
| MSMEG_0317 | Conserved hypothetical protein | 4 | 1.87E+06 | 5.74E+05 | 8.30E+05 | 4.95E+05 | 0.31 |
| MSMEG_0394 | Hypothetical protein | 27 | 1.07E+06 | 2.53E+05 | 6.73E+05 | 4.81E+05 | 0.24 |
| MSMEG_0987 | Hypothetical protein | 2 | 7.68E+05 | 3.00E+02 | 1.45E+06 | 1.49E+06 | 0.00 |
| MSMEG_1052 | Hypothetical protein | 12 | 1.81E+05 | 1.30E+04 | 3.36E+05 | 3.90E+05 | 0.07ab |
| MSMEG_1445 | 30S ribosomal protein S17 | 2 | 1.94E+05 | 3.00E+02 | 4.34E+04 | 5.69E+04 | 0.00a |
| MSMEG_1605 | Phosphate transport system regulatory protein PhoU (phoU) | 2 | 8.48E+04 | 1.13E+03 | 9.13E+03 | 4.25E+03 | 0.01 |
| MSMEG_1680 | Conserved hypothetical protein | 20 | 8.20E+06 | 2.46E+06 | 3.89E+06 | 4.36E+06 | 0.30 |
| MSMEG_1681 | Endoribonuclease L-PSP superfamily | 156 | 2.57E+07 | 7.57E+06 | 1.90E+07 | 2.68E+07 | 0.29 |
| MSMEG_1682 | Flavin-containing monooxygenase FMO | 62 | 2.66E+07 | 7.76E+06 | 1.12E+06 | 1.34E+06 | 0.29ab |
| MSMEG_1832 | Conserved hypothetical protein | 2 | 3.14E+05 | 3.00E+02 | 4.89E+05 | 4.74E+05 | 0.00 |
| MSMEG_1951 | Conserved domain protein | 14 | 4.67E+05 | 1.50E+05 | 1.29E+06 | 1.41E+06 | 0.32 |
| MSMEG_2116 | PTS system, glucose-specific IIBC component | 6 | 1.56E+05 | 2.98E+04 | 2.63E+05 | 1.72E+05 | 0.19ab |
| MSMEG_2789 | Acetyltransferase, GNAT family | 2 | 1.39E+05 | 3.00E+02 | 1.45E+05 | 1.56E+05 | 0.00a |
| MSMEG_2942 | Glyoxalase-bleomycin resistance protein-dioxygenase superfamily protein | 2 | 2.70E+05 | 3.00E+02 | 1.84E+06 | 1.98E+06 | 0.00ab |
| MSMEG_3962 | Lactate 2-monooxygenase | 64 | 3.15E+07 | 5.44E+06 | 2.00E+07 | 2.37E+07 | 0.17ab |
| MSMEG_4075 | CoA-binding protein | 2 | 1.54E+05 | 2.65E+04 | 5.62E+05 | 3.66E+05 | 0.17a |
| MSMEG_4298 | 3-Methyl-2-oxobutanoate hydroxymethyltransferase (panB) | 53 | 1.69E+08 | 4.48E+07 | 2.11E+06 | 1.36E+06 | 0.27a |
| MSMEG_4476 | Hypothetical protein | 2 | 2.80E+05 | 3.00E+02 | 8.88E+04 | 2.04E+05 | 0.00 |
| MSMEG_4935 | ATP synthase F1, epsilon subunit (atpC) | 41 | 1.33E+07 | 4.26E+06 | 4.53E+06 | 3.98E+06 | 0.32ab |
| MSMEG_4936 | ATP synthase F1, beta subunit (atpD) | 190 | 1.01E+08 | 3.19E+07 | 4.31E+07 | 4.67E+07 | 0.31ab |
| MSMEG_5006 | Phosphohistidine phosphatase | 2 | 8.29E+04 | 3.00E+02 | 3.33E+04 | 3.91E+04 | 0.00 |
| MSMEG_5022 | Flavin-containing monooxygenase FMO | 12 | 5.38E+05 | 1.55E+05 | 8.05E+05 | 6.37E+05 | 0.29ab |
| MSMEG_5694 | Conserved hypothetical protein | 2 | 2.52E+05 | 3.00E+02 | 1.82E+06 | 1.28E+06 | 0.00 |
| MSMEG_5703 | Molybdenum cofactor biosynthesis protein C (moaC) | 2 | 9.80E+05 | 3.00E+02 | 7.42E+05 | 1.16E+06 | 0.00a |
| MSMEG_5835 | Fumarate reductase-succinate dehydrogenase flavoprotein | 2 | 6.58E+05 | 1.92E+05 | 1.70E+05 | 5.88E+04 | 0.29a |
| MSMEG_6075 | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF) | 2 | 8.50E+04 | 3.00E+02 | 1.74E+05 | 2.78E+05 | 0.00a |
| MSMEG_6159 | Conserved domain protein | 10 | 6.17E+05 | 2.01E+05 | 4.21E+05 | 1.10E+05 | 0.33a |
| MSMEG_6210 | Conserved hypothetical protein | 2 | 2.75E+05 | 4.46E+04 | 9.40E+05 | 1.13E+06 | 0.16 |
| MSMEG_6457 | Oxidoreductase molybdopterin binding domain, putative | 2 | 6.40E+05 | 1.61E+05 | 4.07E+05 | 3.96E+05 | 0.25a |
| MSMEG_6913 | Putative transcriptional regulatory protein | 2 | 1.99E+05 | 3.00E+02 | 1.19E+05 | 1.67E+05 | 0.00a |
a
Annotated in GO.
b
Present in the unique enriched GO terms (Table 2). PCS_IDs - the number of times peptides from a protein were identified by MS/MS scan.