Table 4.
Comparison of OO and non-OO blood group carriers of FV Leiden (FVL), FII prothrombin (G20210A) and methylenetetrahydrofolate reductase (677TT) as genetic factors for thrombosis
| Blood group genotype and genetic factors for thrombosis | No. (%) of patients with thrombosis (N=154) | No. (%) of controls (N=200) | Odds ratio (95% confidence interval) | P (Fisher test) | Statistical power |
|---|---|---|---|---|---|
| OO and FVL (-) |
30 (19.7) |
85 (42.5) |
1† |
0.99 |
|
| OO and FVL (+) |
11 (7.2) |
1 (0.5) |
31.2 (3.86-251.74) |
<0.001 |
0.91 |
| Non-OO and FVL (-) |
90 (59.3) |
108 (54) |
2.40 (1.40-3.85) |
<0.001 |
0.65 |
| Non-OO and FVL (+) |
21 (13.8) |
6 (3) |
9.92 (3.65-26.91) |
<0.001 |
0.96 |
| OO and FII(-) |
38 (24.7) |
85 (42.5) |
1† |
0.96 |
|
| OO and FII (+) |
3 (1.9) |
1 (0.5) |
6.71 (0.68-66.62)‡ |
0.099 |
0.86 |
| Non-OO and FII (-) |
108 (70.2) |
108 (54) |
2.2 (1.40-3.60) |
<0.001 |
0.88 |
| Non-OO and FII (+) |
5 (3.2) |
6 (3) |
1.86 (0.54-6.48)‡ |
0.330 |
0.76 |
| OO and MTHFR (-) |
33 (21.4) |
72 (36) |
1† |
0.85 |
|
| OO and MTHFR (+) |
8 (5.2) |
14 (7) |
1.25 (0.48 – 3.30)‡ |
0.627 |
0.66 |
| Non-OO and MTHFR (-) |
95 (61.7) |
107 (53.5) |
1.90 (1.20-3.20) |
0.010 |
0.53 |
| Non-OO and MTHFR (+) | 18 (11.7) | 7 (3.5) | 5.61 (2.14-14.73) | <0.001 | 0.86 |
*Abbreviations: FVL – factor V Leiden; FII – prothrombin; MTHFR – methylenetetrahydrofolate reductase.
†Reference category.
‡Statistically non-significant.