Table I.
Summary of Cancer Types Reported in t(11;22) Carriers
| Type of Cancer |
Number of Reported Male Carriers (average age at diagnosis) |
Expected (male) |
p-value (male) |
Number of Reported Female Carriers (average age at diagnosis) |
Expected (female) |
p-value (female) |
Expected (male + female) |
p-value |
|---|---|---|---|---|---|---|---|---|
| Breast | 0 | 0.013 | 1 | 2 (40.5) | 3.34 | 0.51 | - | - |
| Prostate | 2 (70) | 1.59 | 0.69 | n/a | n/a | n/a | n/a | n/a |
| Colorectal | 0 | - | - | 2 (82.5) | - | - | 1.28 | 0.50 |
| Esophageal | 2 (72) | - | - | 0 | - | - | 0.13 | 0.008 |
| Renal | 1 (48) | - | - | 0 | - | - | 0.42 | 0.41 |
| Uterine | n/a | n/a | n/a | 1 (45) | 0.45 | 0.44 | n/a | n/a |
| Ovarian | n/a | n/a | n/a | 1 (55) | 0.28 | 0.28 | n/a | n/a |
| Cervical | n/a | n/a | n/a | 1 (73) | 0.28 | 0.28 | n/a | n/a |
| Leukemia | 0 | - | - | 1 (16) | - | - | 0.48 | 0.47 |
| Melanoma | 1 (72) | - | - | 2 (42.5) | - | - | 0.63 | 0.03 |
U.S. age- and gender-specific cancer incidence rates [United States Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, 2008] were used to compute an expected incidence for each cancer type. The expected and observed numbers of each cancer type were compared and a mid-P exact test [Rothman and Boice, 1979] was used to generate p-values. P-values that reached statistical significance are italicized. n/a= not applicable.