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Efficacy of HBPG against HSV-2 encephalitis in mice after various delays in starting dosing post-infection. HBPG was given twice daily for five days.
Notes: For reduction of mortality, P < 0.05 at one and two days postinfection (Fisher’s exact test). For MDD, P < 0.05 at one and two days postinfection (Mann–Whitney U test).
Abbreviations: HBPG, 2-phenylamino-6-oxo-9-(4-hydroxybutyl)purine; HSV, herpes simplex virus; MDD, mean day of death.
