A. Raw sEPSC recorded from a typical pyramidal cell from either WT or BACHD mice at 6 months postnatal (right, WT=grey, BACHD=black). B & C. Cumulative probability and event distribution histogram of more than 2,400 sequential events illustrate no change in the amplitude or inter-event interval of sEPSC between BACHD and WT mice. Histogram means are indicated (WT=grey, BACHD=black). D. Comparison of the average frequency, amplitude, 10–90% rise time and decay (τ) of sEPSC from all recorded primary motor cortex layer 2/3 pyramidal cells illustrating no differences between WT and BACHD mice. Symbols represent data from individually recorded cells and black bars indicate the group mean.