Table 2.

Synaptic and Passive Properties of Motor Cortex Layer 2/3 Pyramidal Cells and Parvalbumin Interneurons from 6 Month Old Mice.

		Pyramidal Cells		Parvalbumin Interneurons
		WT	BACHD	WT	BACHD
EPSC	Frequency (Hz)	36.3 ± 8.1	31.7 ± 9.0	66.1 ± 23.5 ¤	46.6 ± 16.6 **
	Amplitude (pA)	15.7 ± 2.7	13.8 ± 2.5	17.2 ± 3.4	14.1 ± 2.2 **¤¤
	10–90 RT (ms)	0.72 ± 0.06	0.68 ± 0.07	0.50 ± 0.03	0.53 ± 0.06 *
	Decay (ms)	2.11 ± 0.63	2.24 ± 0.58	0.54 ± 0.08	0.57 ± 0.13
	IMean (pA/sec)	1.38 ± 0.54	0.75 ± 0.30 **‡	1.72 ± 0.90 ‡	0.92 ± 0.44 **#¤¤
	n	12	11	14	17
IPSC	Frequency (Hz)	54.0 ± 11.3 ¤¤	44.9 ± 7.5 **¤	33.5 ± 11.2	33.8 ± 8.2
	Amplitude (pA)	29.9 ± 9.6	29.6 ± 7.6	38.7 ± 13.2	35.5 ± 8.6
	10–90 RT (ms)	0.86 ± 0.12	0.82 ± 0.17	0.63 ± 0.06	0.68 ± 0.08
	Decay (ms)	5.64 ± 1.12	5.20 ± 0.97	2.75 ± 0.53	2.63 ± 0.42
	IMean(pA/sec)	10.62 ± 6.02 ¤¤‡	7.34 ± 3.29 *#	3.63 ± 2.07	4.02 ± 2.28
	n	18	17	12	12
Passive	Input Resist. (MΩ)	64.3 ± 22.3	71.2 ± 17.9	89.7 ± 38.4	102.1 ± 44.5
	τ(ms)	1.88 ± 0.5	1.86 ± 0.4	1.15 ± 0.3	1.21 ± 0.4
	Decay ratio	0.70 ± 0.08	0.72 ± 0.05	0.47 ± 0.09	0.54 ± 0.05 **
	n	23	20	19	17

^**Indicates a significant difference between WT and BACHD within the cell type (Student’s t-Test, p ≤ 0.01)

^*Indicates a significant difference between WT and BACHD within the cell type (Student’s t-Test, p ≤ 0.05)

^#Indicates a significant difference in the variance between WT and BACHD within the cell type (F-test, p ≤ 0.05)

^¤¤Indicates a significant difference between 3 and 6 month old animals within the cell type and genotype (Student’s t-Test, p ≤ 0.01)

^¤Indicates a significant difference between 3 and 6 month old animals within the cell type and genotype (Student’s t-Test, p ≤ 0.05)

^‡Indicates a significant difference in the variance between 3 and 6 month old animals within the cell type and genotype (F-test, p ≤ 0.05)