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Groups of BALB/c mice were exposed to TBI alone (7 Gy) alone or in combination with VPA at 200, 400 or 600 mg/kg. When VPA followed TBI by 1 h, a dose of at least 400 mg/kg resulted in increased survival. VPA at 200 mg/kg was not effective (P < 0.05 compared with VPA at 400 mg/kg, log rank test). The figure illustrates the increased survival after 7 Gy TBI when TSA (0.5 mg/kg) was administered 24 h before TBI.
