Table VI.

Antinociceptive Effect of Tramadol HCl

Rat	AUC0–48 h
	Control	Oral	Transdermal
	Group 1	Group 2	Group 3	Group 4
1	6.60	104.98	720.00	1,547.23
2	9.68	133.15	685.27	1,404.76
3	7.14	148.90	785.41	1,235.84
4	14.76	146.37	881.46	1,600.74
5	7.63	113.24	816.57	1,205.18
6	3.78	126.11	608.00	1,410.47
Mean	8.27	128.71	749.45	1,400.70
SD (±)	3.38	16.22	89.66	145.54

AUC _(0–48 h) area under the plasma concentration–time curve from 0 to 48 h, SD standard deviation