Table I.
Composition of Dorzolamide Hydrochloride-Loaded Nanoemulsions
| Component (% w/w) | Nanoemulsion (NE) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | |
| IPM | 2.00 | 2.00 | 2.00 | 2.00 | |||||||||||||
| Triacetin | 4.50 | 4.50 | 2.00 | 4.00 | 2.00 | 4.00 | 2.00 | 2.00 | 4.00 | 2.00 | 4.00 | 2.00 | 4.00 | 2.00 | 4.00 | ||
| TW80 | 13.50 | 13.50 | 13.50 | 6.75 | 13.50 | 12.00 | 13.50 | 12.00 | 13.50 | 6.75 | 6.00 | 6.75 | 6.00 | ||||
| CrEL | 6.75 | 13.50 | 12.00 | 13.50 | 12.00 | 6.75 | 6.00 | 6.75 | 6.00 | ||||||||
| PG | 4.50 | 4.50 | 4.00 | 4.50 | 4.00 | 4.50 | 4.00 | ||||||||||
| Transcutol | 4.50 | 4.50 | 4.00 | 4.50 | 4.00 | 4.50 | 4.00 | ||||||||||
| Miranol | 4.50 | ||||||||||||||||
Bidistilled deionized water was used as the aqueous phase (77.78% w/w). Dorzolamide hydrochloride was used in a concentration of 2.22% w/w
IPM (isopropyl myristate); Tween 80 (TW80); Cremophor EL (CrEL); PG (Propylene glycol)