Table I.
Tablet Formulations for Preliminary Trials
| Formulation | Drug | HPMC K4 M | HPMC E 15 LV | HPC | Xanthan gum | Sodium alginate | NaHCO3 | Mannitol | Magnesium stearate |
|---|---|---|---|---|---|---|---|---|---|
| I | 40 | 60 | – | – | – | – | 20 | 78 | 2 |
| II | 40 | 80 | – | – | – | – | 20 | 58 | 2 |
| III | 40 | 100 | – | – | – | – | 20 | 38 | 2 |
| IV | 40 | – | 60 | – | – | – | 20 | 78 | 2 |
| V | 40 | – | 80 | – | – | – | 20 | 58 | 2 |
| VI | 40 | – | 100 | – | – | – | 20 | 38 | 2 |
| VII | 40 | – | – | 60 | – | – | 20 | 78 | 2 |
| VIII | 40 | – | – | 80 | – | – | 20 | 58 | 2 |
| IX | 40 | – | – | 100 | – | – | 20 | 38 | 2 |
| X | 40 | – | – | – | 60 | – | 20 | 78 | 2 |
| XI | 40 | – | – | – | 80 | – | 20 | 58 | 2 |
| XII | 40 | – | – | – | 100 | – | 20 | 38 | 2 |
| XIII | 40 | – | – | – | – | 60 | 20 | 78 | 2 |
| XIV | 40 | – | – | – | – | 80 | 20 | 58 | 2 |
| XV | 40 | – | – | – | – | 100 | 20 | 38 | 2 |
Total weight of tablet 200 mg. All weights in milligrams
HPMC hydroxypropyl methyl cellulose, HPC hydroxypropyl cellulose