Table II.
Formulation | Time (h) | Initial W t (W 0) (mg) | Final W t (W t) (mg) | Water uptake |
---|---|---|---|---|
Preliminary formulations | ||||
II (HPMC K4 M 30%) | 2 | 204 | 403 | 97.54 |
4 | 201 | 561 | 178.910 | |
6 | 196 | 689 | 251.53 | |
8 | 298 | 791 | 299.49 | |
III (HPMC K4 M 40%) | 2 | 201 | 536 | 166.66 |
4 | 193 | 666 | 245.07 | |
6 | 198 | 805 | 306.56 | |
8 | 196 | 912 | 365.30 | |
X (XG 30%) | 2 | 205 | 519 | 188.29 |
4 | 193 | 678 | 251.29 | |
6 | 195 | 787 | 303.54 | |
8 | 199 | 865 | 334.67 | |
XI (XG 40%) | 2 | 196 | 598 | 205.10 |
4 | 198 | 752 | 279.79 | |
6 | 205 | 834 | 306.82 | |
8 | 201 | 901 | 348.25 | |
XII (XG 50%) | 2 | 201 | 659 | 227.86 |
4 | 206 | 881 | 327.66 | |
6 | 199 | 1,051 | 428.14 | |
8 | 201 | 1,189 | 491.54 | |
Formulations of floating tablets | ||||
F I | 2 | 305 | 819 | 168.52 |
4 | 291 | 752 | 293.12 | |
6 | 293 | 823 | 348.80 | |
8 | 294 | 901 | 413.60 | |
F II | 2 | 295 | 838 | 184.06 |
4 | 291 | 1,126 | 286.94 | |
6 | 299 | 1,288 | 330.76 | |
8 | 295 | 1,478 | 401.00 | |
F III | 2 | 289 | 811 | 180.62 |
4 | 299 | 1,094 | 265.88 | |
6 | 304 | 1,259 | 314.14 | |
8 | 297 | 1,426 | 380.13 | |
F IV | 2 | 294 | 804 | 173.46 |
4 | 293 | 1,096 | 274.06 | |
6 | 299 | 1,303 | 357.78 | |
8 | 302 | 1,491 | 393.70 | |
F V | 2 | 299 | 817 | 173.24 |
4 | 295 | 1,119 | 270.32 | |
6 | 295 | 1,305 | 343.37 | |
8 | 298 | 1,489 | 399.66 |
n = 3
HPMC hydroxypropyl methyl cellulose, F formulation