Table II.
Evaluation of Chitosan–TPP-Sustained Release Beads Prepared as per 32 Full Factorial Design
| Formulation code | Coded factor level | Percent entrapment efficiency (n = 3) | Particle size (μm; n = 100) | Release at 12 h (n = 3) | Release exponent (n) | Kinetic constant (k) | |
|---|---|---|---|---|---|---|---|
| Factor 1 | Factor 2 | ||||||
| B1 | −1 | −1 | 79.37 ± 0.36 | 689.7 ± 0.43 | 95.036 ± 0.26 | 6.8278 | 0.7071 |
| B2 | −1 | 0 | 80.82 ± 0.73 | 698.02 ± 0.89 | 92.644 ± 0.42 | 5.8127 | 0.7567 |
| B3 | −1 | 1 | 82.59 ± 0.53 | 659.82 ± 0.50 | 93.21 ± 0.45 | 5.3744 | 0.7836 |
| B4 | 0 | −1 | 85.12 ± 0.74 | 762.9 ± 0.24 | 91.288 ± 0.63 | 5.479 | 0.7122 |
| B5 | 0 | 0 | 86.36 ± 0.33 | 739.54 ± 0.56 | 94.611 ± 0.26 | 5.4385 | 0.7185 |
| B6 | 0 | 1 | 87.77 ± 0.26 | 709.91 ± 0.51 | 93.295 ± 0.84 | 4.2077 | 0.7415 |
| B7 | 1 | −1 | 91.23 ± 0.21 | 889.22 ± 0.45 | 89.727 ± 0.27 | 4.8265 | 0.7624 |
| B8 | 1 | 0 | 91.59 ± 0.34 | 768.27 ± 0.98 | 85.976 ± 0.53 | 4.6484 | 0.7595 |
| B9 | 1 | 1 | 92.81 ± 0.43 | 749.91 ± 0.17 | 79.718 ± 0.33 | 2.3836 | 0.767 |
TPP tripolyphosphate
Mean ± SD