Table II.

3³ Full Factorial Design of In Situ Forming Formulation

Coded value	Actual values
	X 1 (% w/v)	X 2 (% w/v)	X 3 (% w/v)
High (+1)	2.25	0.50	5.0
Medium (0)	1.75	0.25	3.75
Low (−1)	1.25	0	2.5

All batches contained 1.5% w/v of calcium carbonate

X ₁ sodium alginate; X ₂ gellan gum; X ₃ metfomin