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. 2009 Oct 1;85(3):454–463. doi: 10.1093/cvr/cvp324

Figure 6.

Figure 6

CaMKII enhanced late INa. Late INa was elicited by 800 ms depolarizations to −20 mV (from −140 mV), and TTX-sensitive currents were normalized to peak INa. (A) Representative normalized TTX-sensitive current in control and CaMKII-containing pipette solution. (B) The average amplitude of the late current between the 100 and 500 ms was normalized to the peak INa. CaMKII (n = 7) significantly increased the late INa compared with control (n = 7), and the addition of AIP (n = 4) abolished the CaMKII-induced increase in late INa. CaM (n = 5) and PKA (n = 5) did not change the late INa.