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. 2009 Oct 8;85(3):514–519. doi: 10.1093/cvr/cvp337

Figure 1.

Figure 1

Resveratrol induces the expression of KLF2 and KLF2-dependent endothelial atheroprotective genes. (A) KLF2 mRNA levels in HUVEC cultured for 8 h with 10, 50, 100, and 250 µM of resveratrol and compared with ethanol vehicle treatment (*P < 0.05 vs. ethanol control; n = 3; ANOVA, Tukey's HSD test). (B) KLF2 expression in HUVEC incubated with 100 µM resveratrol for the indicated periods of time (*P < 0.05 vs. its time-corresponding ethanol vehicle control; n = 4; Student's t-test). (C) Expression of known KLF2 targets in HUVEC after 24 h of resveratrol (100 µM) stimulation (*P < 0.05 vs. ethanol vehicle control; n = 3; Student's t-test). (D) Effect of KLF2 silencing on expression of resveratrol-induced vasoprotective targets (*P < 0.05; n = 3; ANOVA, Tukey's HSD test). Data expressed as mean ± SEM.