Table 1.

Association of prostate cancer risk with SNPs rs10896449 at locus 1 and rs12418451 at locus 2

	Risk	Genotype counts						Heterozygotes		Homozygotes		Allele frequency
Populations	Allele	Cases			Controls			OR	95% CI	OR	95% CI	Cases	Control	P*	P^	I2 #
rs10896449		AA	AG	GG	AA	AG	GG	AG vs AA		GG vs AA		G	G
CAPS	G	748	1362	710	477	867	342	1.00	0.87–1.16	1.32	1.11–1.57	0.49	0.46	2.20E-03
JHH	G	293	706	508	113	233	130	1.17	0.90–1.52	1.51	1.13–2.01	0.57	0.52	3.80E-03
CPS-II	G	339	868	553	427	878	469	1.43	1.16–1.76	1.48	1.17–1.86	0.56	0.51	3.70E-05
PLCO	G	240	598	328	298	519	276	1.25	1.05–1.48	1.49	1.23–1.79	0.54	0.49	1.30E-03
ALL	G	1620	3534	2099	1315	2497	1217	1.16	1.06–1.27	1.42	1.28–1.58	0.53	0.49	1.60E-11	0.56	0
rs12418451		GG	AG	AA	GG	AG	AA	AG vs GG		AA vs GG		A	A
CAPS	A	1392	1227	262	930	658	126	1.25	1.10–1.41	1.39	1.11–1.75	0.30	0.27	8.60E-05
JHH	A	715	644	155	231	215	32	0.97	0.78–1.2	1.56	1.04–2.35	0.32	0.29	1.80E-01
CPS-II	A	704	608	124	756	562	116	1.09	0.91–1.3	1.47	1.08–2.01	0.30	0.28	8.00E-02
PLCO	A	519	506	113	527	472	78	1.16	1.00–1.36	1.15	0.87–1.51	0.32	0.29	3.00E-02
ALL	A	3330	2985	654	2444	1907	352	1.15	1.06–1.24	1.36	1.18–1.56	0.31	0.28	1.20E-06	0.68	0

P*: Based on an allelic test assuming a multiplicative model. The combined tests are based on a Mantel-Haenszel test.

P^: Breslow-Day test for homogeneity

I^2#: Percentage of total variation across studies that is due to heterogeneity rather than chance