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Early and Late Phases of Endpoint Validation
| Attribute | Early Phase Validation | Late Phase Validation |
|---|---|---|
| Goal | Individual patient level outcome prediction | Trial level outcome prediction |
| Setting | Single randomized trials or uniformly treated patients from non-randomized trials | Meta-analysis of randomized clinical trials |
| Methods | Correlation analyses between endpoints within patients | Correlation analyses between trial level effects on both endpoints |
