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IL-6 action frees helper and effector T cells from the suppressive effects of IL-10 secreted by Treg cells. High levels of IL-6 protein and its soluble receptor in CRS with nasal polyps suggest the hypothesis that local increases in IL-6 activity may dampen local immunosuppression fostering polyp formation. (Illustration by William E. Walsh, MD, CMI, 2008 William Walsh; used with permission.)
