Figure 4.

Paired- and multipulse depression was reduced at interneuron-to-granule cell synapses in epileptic mice. A, Trains of uIPSCs recorded in granule cells and generated by green fluorescent protein-positive hilar somatostatin interneurons in slices from control and epileptic pilocarpine-treated GIN mice. Action potentials (20) were evoked in interneurons at 50 Hz every 10 s. At least 20 traces were recorded and averaged. Average amplitudes of the first, second, and 20th uIPSCs were measured. B, Paired- and multipulse amplitude ratios were larger in epileptic mice (*p < 0.009, t test, n = 8 control, 15 epileptic mice).