TABLE 1.

Effect of inhibitors of FLX-1-O-G and FLX-CoA formation on the production of FLX-SG in incubations of (R)-(−)-FLX (10 μM) with rat hepatocytes (2 million cells/ml, 6-min incubation time)

Values are expressed as the mean ± S.D. from three incubations.

Inhibitor	FLX-1-O-G		FLX-CoA		FLX-SG
	Conc.	%Control	Conc.	% Control	Conc.	%Control
	nM		nM		nM
Control	N.D.		24.0 ± 1.20		1.60 ± 0.50
(−)-Borneol (100 μM)	N.D.	2.50 ± 0.50	24.1 ± 4.60	100 ± 19.2	1.57 ± 0.26	98.4 ± 16.1
Lauric acid (1000 μM)	N.D.	12.5 ± 0.70	0.00	0.00	0.04 ± 0.06	2.3 ± 4.1

N.D., not determined.