TABLE 4.

Discovery and validation of novel genes associated with drug sensitivity using cell-based models

Drugs	Target Gene	Effect	Ref
AraC	SLC25A37	↑ expression leads to ↑ drug sensitivity	Hartford et al., 2009
Daunorubicin	CYP1B1	↓ expression leads to ↑ drug sensitivity	Huang et al., 2008b
Gemcitabine, AraC	NT5C3	↓ expression leads to ↑ sensitivity	Li et al., 2008
Gemcitabine, AraC	FKBP5	↓ expression leads to ↓ sensitivity	Li et al., 2008
Carboplatin	CD44	↓ expression leads to ↑ sensitivity	Shukla et al., 2009
Azacytidine, Inosine-glycodialdehyde	SLC29A1/ENT1	Treatment with tight binding inhibitor reduces drug sensitivity	Huang et al., 2004
Paclitaxel, bisantrene, geldanamycin analog, Baker's antifol	ABCB1	↓ expression leads to ↑ drug sensitivity	Huang et al., 2004
Camptothecin	ABCB5	↓ expression leads to ↑ drug sensitivity	Huang et al., 2004