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. 2009 Dec;61(4):413–429. doi: 10.1124/pr.109.001461

TABLE 6.

Useful databases for cell-based pharmacogenetics

Database URL Description
HapMap http://www.ncbi.nlm.nih.gov/geo/ Basal expression data for HapMap samples using various microarray expression platforms
http://www.hapmap.org/ Genetic variation data of >4 million SNPs
PharmGKB http://www.pharmgkb.org/ Genotype and drug phenotype data for >600 genes, 500 drugs, and 500 diseases
NCI60 https://dtp.nci.nih.gov/ SNP, expression, and CNV data on 59 cell lines from various tissues, as well as cytotoxicity data for over 40,000 compounds
http://discover.nci.nih.gov/ Free bioinformatics and data mining tools for use with the genetic and drug phenotype data
SCANdb http://www.SCANdb.org Results of genomewide association studies between basal expression of over 13,000 transcripts and genotypes of hundreds of thousands of SNPs in the HapMap CEU and YRI samples
Cancer Genome Project http://www.sanger.ac.uk/genetics/CGP/ Collection of somatically acquired mutations and other sequence variants in genes that drive oncogenesis
VIP Genes and 1000 Genomes http://genemed1.bsd.uchicago.edu/pharmacodb/thougen/main.php Organizes the results of high-coverage, deep resequencing of 39 VIP genes in four subjects from the 1000 Genomes project, as well as lower coverage resequencing of 57 other subjects