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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Curr Gene Ther. 2009 Oct;9(5):341–355. doi: 10.2174/156652309789753329

Figure 2. Difference between normal and tumor vasculature.

Figure 2

Athymic nude mice with intracranial U87ΔEGFR glioma cell tumors were sacrificed when the mice showed evidence of tumor burden. The harvested tissue including tumor and normal brain was fixed and stained for CD31 endothelial marker (brown) and counterstained with hematoxylin. A: Highlights the regular thickness of vasculature in the normal, non-tumor bearing hemisphere. Note the uniform distribution, and regular thickness of the vasculature. B: Tumor vasculature resulting from the uncontrolled secretion of angiogenic factors is highly aberrant. Note the large extended lumens, irregular thickness, tortuous structure and very high blood vessel density.