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A, effect of l-NMMA, ISDN, and sildenafil on net t-PA response to exogenous bradykinin in all subjects. Effect of l-NMMA on t-PA response to exogenous bradykinin in women (B) and men (C). The increase in bradykinin-stimulated t-PA release in the presence of l-NMMA was significantly greater in women compared with men (F = 6.7, P = 0.02).
