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. 2010 Jan;332(1):4–16. doi: 10.1124/jpet.109.158303

Fig. 2.

Fig. 2.

Mean daily number of self-injections delivered on the last 5 days of the 15-day period of availability of TPA123, lorazepam, TPA023, or their vehicles (V) in each of four baboons and for the group. Each self-injection was available under an FR-160 schedule of reinforcement; a time-out of 180 min followed completion of the response requirement, which limited maximal injections/day to eight. Each test dose or V was substituted for 0.32 mg/kg cocaine, which had maintained six to eight self-injections/day for the three preceding days (data not shown). Vertical bars indicate 1 S.D. for the individual baboons and 1 S.E.M. for the group means. Food pellets were concurrently available under a separate schedule of reinforcement (Fig. 3). TPA123 V for the second determinations for baboons GD and TZ are for the last 5 days in which vehicle was substituted directly for a dose of TPA123 (Fig. 4). TPA023 V for LC was not included due to his removal from the study for treatment of infection during that condition.

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