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. 2010 Jan;332(1):4–16. doi: 10.1124/jpet.109.158303

Table 1.

GABAA/benzodiazepine receptor occupancy after intravenous administration of TPA023 in baboons

Specific binding was estimated 20 min after TPA023 administration and 60 min after [11C]flumazenil injection.

Baboon TPA023 Dose Frontal Cortex Parietal Cortex Temporal Cortex Occipital Cortex Cerebellum Avg. ± S.D.
mg/kg %
1 0.0032 11 10 16 13 19 14 ± 4
0.032 63 68 70 69 76 69 ± 5
0.32 99 98 98 97 99 98 ± 1
2 0.0032 5 5 4 6 12 6 ± 3
0.032 58 64 65 62 70 64 ± 5
0.32 98 99 99 97 99 98 ± 1
3 0.0032 8 8 5 10 16 9 ± 4
0.032 44 46 50 51 64 51 ± 8
0.32 95 95 95 94 96 95 ± 1
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