Fig. 4.
Lack of TMF agonist activity is independent of dose. A, HepG2 (40/6) cells were treated with vehicle (DMSO) or increasing concentrations of either TMF or α-NF, as indicated for 6 h; cells were lysed, and luciferase activity was determined. Data represent mean luciferase units ± S.E.M. and were normalized for protein concentration. B, HepG2 (40/6) cells were treated with vehicle (DMSO), 2 nM TCDD, or 10 μM TMF, as indicated, for 24 h; cells were lysed, and luciferase activity was determined. Data represent mean luciferase units ± S.E.M.